Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy) <sub>3</sub> <sup>2+</sup> Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER
Reactive oxygen species (ROS) have gained increasing attention in electrochemiluminescence (ECL) as endogenous co-reactants, yet their application in the most widely used tris(bipyridine)-ruthenium(II) system remains limited due to the scarcity of suitable co-reactant accelerators (CRAs) with selective oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic activity. Here, this work reports a series of facet-tunable homogeneous NiNPs catalysts, which can stimulate ECL at distinguishable cathodic/anodic potentials in tris(bipyridine)-ruthenium(II) system. Experimental studies and theoretical calculation results reveal that the Ni(1 1 0) surface, with its lower charge density, impedes the fourth step of 4e<sup>-</sup> ORR, thus favoring 2e<sup>-</sup> pathway and consequently promoting substantial ROS generation and ECL at the cathode. Conversely, the Ni(1 1 1) and (2 0 0) surface prompt robust and stable anodic ECL via hydroxyl radical by controlling the OER. These excellent CRAs link cathodic/anodic ECL with ORR/OER, offering a novel strategy for precisely designing predictable non-precious metal CRAs. Furthermore, sensitive immunosensors were developed using these CRAs, demonstrating successful application in potential-resolved ECL analysis for practical purposes.
Authors
- Lingfang Jiang
- Anna Malashicheva (ORCID: https://orcid.org/0000-0002-0820-2913)
- Hao Sun (ORCID: https://orcid.org/0000-0003-0189-1784)
- Zhu Shu (ORCID: https://orcid.org/0000-0002-5269-2323)
- Xiaoyong Tong (ORCID: https://orcid.org/0000-0002-0553-6723)
- Ziqi Kang (ORCID: https://orcid.org/0009-0003-2084-610X)
- Shijun Wang (ORCID: https://orcid.org/0000-0002-5920-4118)
- Zixin Deng (ORCID: https://orcid.org/0000-0003-0724-3390)
- Dong Feng (ORCID: https://orcid.org/0000-0003-3773-1352)
- Yangkun Liu (ORCID: https://orcid.org/0000-0001-9430-9401)
- Guixue Wang (ORCID: https://orcid.org/0000-0003-1883-8023)
- Chenzhong Li (ORCID: https://orcid.org/0000-0002-0486-4530)
- Yihong Zhang (ORCID: https://orcid.org/0000-0002-6432-3840)
- Yu Du (ORCID: https://orcid.org/0000-0002-1611-4382)
- Zixu Wang (ORCID: https://orcid.org/0009-0006-1327-6366)
- Zhizhi Xiang
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Chengdu Medical College (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Institute of Cytology (RU)
- Chinese University of Hong Kong, Shenzhen (CN)
- Ministry of Education (TH)
- The London College (GB)
- BioElectronics (United States) (US)
- University College London (GB)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Exploration
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1002/exp.20250036
- Citations
- 8
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Soochow University
- Chongqing Municipal Education Commission
- Centre Scientifique et Technique du Bâtiment
- Fundamental Research Funds for the Central Universities