THE ROLE OF PHYTOCOSTITUENTS IN COVID-19 MANAGEMENT

Background: One of the most lethal contagious diseases is COVID-19, a devastating global pandemic brought on by the SARS-CoV-2 virus.The discovery of therapeutic alternatives has become crucial because to the significant threat to global public health, and a worldwide race to find a cure has mobilised researchers from many disciplines. Scope and approach:The purpose of this study is to assess the therapeutic potential of a number of secondary metabolites like terpenoids, phenolic compounds, alkaloids, glycosides and sulphur-containing compound derived from medicinal plants as inhibitors of SARS-CoV-2 therapeutic targets or as blockers of viral particle entry via host cell receptors.Utilising medicinal plants with specific phytoconstituents may offer the populace a long-term, safer alternative with fewer side effects.Key Findings and Conclusions: Despite the pricey and tedious nature of drug discovery, therapeutic repurposing of current medications was investigated as a therapy option in COVID-19; however, some compounds were withdrawn as therapeutics as a result of either no favourable outcomes or significant adverse effects.These consequences need the investigation of alternative therapy approaches that are both therapeutically effective and safe.Bearing this in mind, phyto-pharmaceuticals produced from medicinal plants might be investigated as essential resources in the development of COVID-19 therapy, since their function in the treatment of viral infections like as HIV, MERS-CoV, and influenza has been extensively documented in the past.Regarding this, many plant-based components, including flavonoids, alkaloids,