Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy
Baseline clinical severity and brain atrophy could not predict individual clinical progression, suggesting no need for MRI-based stratification of patients in future PSP trials. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Nicholas Seneca
- Andrea Quattrone (ORCID: https://orcid.org/0000-0003-2071-2083)
- Hans‐Jürgen Huppertz (ORCID: https://orcid.org/0000-0003-3856-9094)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Gabor C. Petzold (ORCID: https://orcid.org/0000-0002-0145-8641)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Johannes Prudlo (ORCID: https://orcid.org/0000-0002-7932-5929)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- AbbVie (United States) (US)
- LMU Klinikum (DE)
- Magna Graecia University (IT)
- Munich Cluster for Systems Neurology (DE)
- Swiss Epilepsy Center (CH)
- University College London (GB)
- University of Rostock (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1002/mds.70026
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- University of Pennsylvania
- Universidade de Aveiro
- Johns Hopkins University
- Pennsylvania State University
- University of Ottawa
- Rush University
- Deutsches Krebsforschungszentrum
- Korea University Guro Hospital
- Ochsner Health
- Imperial College London
- University College London
- Deutsche Forschungsgemeinschaft
- Volkswagen Foundation
- Eberhard Karls Universität Tübingen
- Korea University
- Technische Universität Dresden
- Forschungszentrum Jülich
- Ministero della Salute
- University of Toronto
- Eisai
- Universidad de Navarra
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Technische Universität München
- Ludwig-Maximilians-Universität München
- Humboldt-Universität zu Berlin
- Freie Universität Berlin
- Universität zu Köln
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Universität Ulm
- Centre Hospitalier Universitaire de Bordeaux
- Servier
- Deutschen Konsortium für Translationale Krebsforschung
- Universitätsklinikum Köln
- Universität Rostock
- H. Lundbeck A/S
- Institute for Translational Neuroscience
- Bayer Vital
- Leibniz-Gemeinschaft
- School of Public Health, Imperial College London
- NIH Clinical Center