An integrative approach to neuroprotection in Alzheimer’s disease: Biochemical synergy between creatine and magnesium l-Threonate

Alzheimer's Disease (AD) is a progressive neurodegenerative condition that causes memory loss, cognitive decline, and changes in behavior. Because there are no cures, prevention, and early intervention strategies are becoming more essential. This article examines the combined effects of supplementation with creatine and magnesium L-threonate on neuroprotection and the treatment of Alzheimer's disease, from a biochemistry perspective and the most recent scientific evidence. Creatine affects the bioenergetics of neurons, the stability of mitochondria, and the function of synapses. Magnesium L-threonate, on the other hand, raises magnesium levels in the brain, which changes how synapses function, how neurons fire, and the development of inflammation. This literature review demonstrates that these substances work together to affect pathways like oxidative phosphorylation, N-methyl-D-aspartate (NMDA) receptor modulation and brain-derived neurotrophic factor (BDNF) expression and slowing the development of neuroinflammation. The integrated supplemental approach is a promising and safe way to improve brain health, especially for people who are at elevated risk for Alzheimer's or are in the initial stages of the disease.