IMPACT OF LIPID PROFILE IN HYPERGLYCEMIC PATIENTS

Introduction- Type 2 diabetes mellitus (T2DM) is a syndrome of abnormal carbohydrate, fat and protein metabolism. T2DM is caused by absolute or relative lack of insulin and is a major public health concern. [1] According to the last International Diabetes Federation (IDF) report, the rate of diabetic patients will reach to 438 million patients worldwide in 2030. [2] Type 2 diabetes can be treated but due to its long-term complications, it causes many risks to health. Prolonged high sugar level in T2DM can affect the immune, cardiovascular, renal and ophthalmic systems, leading to complications like neuropathy, peripheral vascular disease, renal disease, retinopathy and coronary heart disease. Diabetic patients are highly prevalent to cardiovascular disease. [3-4]   Aim- Impact of Lipid Profile in Hyperglycemic patients   Material and Method- This research was conducted on 200 samples from individuals with type 2 diabetes mellitus and controls from medically fit subjects. Patients conducted at Biochemistry department in collaboration with Medicine Department at Index Medical College, Indore.   Result- In this study FBS were found highly significant [<0.0001] in case 222.74±21.01 (Mean±SD) as comparision of healthy person (Mean±SD) 86.44±8.75. TC were found significant [<0.0001] in case 281.23±13.07 (Mean±SD) as comparisons of healthy person 166.17±12.65 (Mean±SD). TG were found significant [<0.0001] in case 359.30±62.54 (Mean±SD) as comparisons of healthy person 115.09±11.55 (Mean±SD). HDL were found significant [<0.0001] in case 28.37±6.13 (Mean±SD) as comparisons of healthy person39.37±4.91(Mean±SD). LDL were found significant [<0.0001] in case 172.37±15.97(Mean±SD) as comparisons of healthy person 105.27±15.80(Mean±SD). VLDL were found significant [<0.0001] in case 48.85±4.71(Mean±SD) as comparisons of healthy person23.11±2.21(Mean±SD).   Conclusion- Type 2 diabetes mellitus patients, as well as in all patients with unexpected worsening of their lipid profile or vice-versa because our data statistically suggest that the effect of Plasma glucose associated with lipid disorders that are characterized by increased TC, Triglycerides, LDL-C, VLDL-C and decreased HDL-C levels