Aminonaphthoquinone: A Versatile Synthon for the Synthesis of Naphthoquinone-fused <I>N</I>-heterocycles <i>via</i> Multicomponent Reactions (MCRs)
The naphthoquinone-fused <I>N</I>-heterocycles are found in natural products and are important candidates in medicinal chemistry. The 1, 3-C, N-binucleophilic property of the 2-aminonaphthoquinone provides access for the synthesis of naphthoquinone-fused <I>N</I>-heterocycles. In recent years this property of 2-aminonaphthoquinone has been acknowledged greatly by the synthetic community for construction of variably dubstituted naphthoquinone-fused <I>N</I>-heterocycles. This review summarizes the important findings in this area during 2019-2024. Also the review highlights the gap and future perspective of the approach.
Authors
- Bibhuti Bhusan Parida (ORCID: https://orcid.org/0000-0001-8623-0429)
- Bibekananda Das
- Swadhin Swaraj Acharya (ORCID: https://orcid.org/0009-0009-3607-6369)
Institutions
- Berhampur University (IN)
Publication Details
- Journal
- American Journal of Heterocyclic Chemistry
- Published
- 2025-08-28
- DOI
- https://doi.org/10.11648/j.ajhc.20251002.11
- Citations
- 3
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Indian Institute of Technology, Patna
- Indian Institute of Science Education and Research Thiruvananthapuram
- Indian Institute of Science Education and Research Mohali
- Science and Engineering Research Board