Peri-articular injection of high-dose tranexamic acid after total knee arthroplasty reduces blood loss and transfusion rate
PAI of TXA, either alone or in combination with IAI, is more effective in reducing postoperative blood loss in TKA procedures than IAI alone. These findings support the use of PAI, particularly with a higher dose of 2 g TXA, as a safe and effective method for minimizing drainage output in patients undergoing TKA.
Authors
- Kun-Han Lee (ORCID: https://orcid.org/0000-0002-0951-8610)
- Po‐Kuei Wu (ORCID: https://orcid.org/0000-0003-2515-8341)
- Cheng‐Fong Chen (ORCID: https://orcid.org/0000-0002-2485-6159)
- Wei-Ming Chen (ORCID: https://orcid.org/0000-0001-7177-4167)
- Yu-Kuan Lin
- Shang-Wen Tsai
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s13018-025-06242-9
- Citations
- 1
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.87