Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
Among patients with nonobstructive HCM, mavacamten did not result in a significantly greater improvement in peak oxygen uptake or decrease in symptoms than placebo. (Funded by Bristol Myers Squibb; ODYSSEY-HCM ClinicalTrials.gov number, NCT05582395.).
Authors
- Fábio Danziato Fernandes (ORCID: https://orcid.org/0000-0002-9323-8805)
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0001-8966-6906)
- Olga Azevedo (ORCID: https://orcid.org/0000-0002-6784-3403)
- Perry Elliott (ORCID: https://orcid.org/0000-0003-3383-3984)
- Yue Zhong (ORCID: https://orcid.org/0000-0002-9839-0160)
- Jonathan Myers (ORCID: https://orcid.org/0000-0003-2592-136X)
- Thomas A. Rano
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Milind Y. Desai (ORCID: https://orcid.org/0000-0003-0010-9797)
- Hiroaki Kitaoka
- Lisa Mitchell
- Benjamin Meder (ORCID: https://orcid.org/0000-0003-0741-2633)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Steven E. Nissen (ORCID: https://orcid.org/0000-0002-7231-6464)
- Ron Aronson
- Victoria Florea (ORCID: https://orcid.org/0000-0001-5656-8381)
- Nicolas Verheyen (ORCID: https://orcid.org/0000-0001-7414-4056)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Renato D. Lópes (ORCID: https://orcid.org/0000-0003-2999-4961)
- Wael A. Jaber (ORCID: https://orcid.org/0000-0001-5642-2112)
- Qiuqing Wang
- Zhiqun Gong
- Kathy Wolski
- Lars S. Maier
- Suzanne Carter-Bonanza
Institutions
- Cleveland Clinic (US)
- Duke University (US)
- University of California, San Francisco (US)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital Regensburg (DE)
- Kochi Medical School Hospital (JP)
- Palo Alto Veterans Institute for Research (US)
- Bristol-Myers Squibb (United States) (US)
- Hospital da Senhora da Oliveira Guimarães (PT)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Meyer Children's Hospital (IT)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- University College London (GB)
- University of Regensburg (DE)
- University of San Francisco (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1056/nejmoa2505927
- Citations
- 30
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 41.65
Funders
- Bristol-Myers Squibb Foundation