Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy
Among patients with symptomatic obstructive HCM, aficamten monotherapy was superior to metoprolol monotherapy in improving peak oxygen uptake and hemodynamics and decreasing symptoms. (Funded by Cytokinetics; MAPLE-HCM ClinicalTrials.gov number, NCT05767346.).
Authors
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Perry Elliott (ORCID: https://orcid.org/0000-0003-3383-3984)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- P. Christian Schulze
- Ajith Nair (ORCID: https://orcid.org/0000-0002-3755-4985)
- Amy Wohltman
- Ozlem Bilen (ORCID: https://orcid.org/0000-0002-3078-5262)
- Melissa Burroughs
- Steen Hvitfeldt Poulsen (ORCID: https://orcid.org/0000-0002-9586-835X)
- Anne M. Dybro (ORCID: https://orcid.org/0000-0003-3175-9725)
- Andrew Z. Wang (ORCID: https://orcid.org/0000-0002-9781-4494)
- Regina Sohn
- Juan Pablo Costabel (ORCID: https://orcid.org/0000-0003-0073-5739)
- Edileide de Barros Correia (ORCID: https://orcid.org/0000-0001-6414-8838)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Michael A. Fifer (ORCID: https://orcid.org/0000-0002-8363-445X)
- Zi Michael Miao (ORCID: https://orcid.org/0000-0002-2377-1444)
- Indrias Berhane
- Sheila M. Hegde (ORCID: https://orcid.org/0000-0001-8157-8899)
- Béla Péter Merkely (ORCID: https://orcid.org/0000-0001-6514-0723)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- Amy Mann
- Patricia Réant (ORCID: https://orcid.org/0000-0003-4897-1036)
- Gregory D. Lewis
- María Luisa Peña‐Peña
- Neal K. Lakdawala
Institutions
- Semmelweis University (HU)
- Brigham and Women's Hospital (US)
- WellStar Health System (US)
- St Bartholomew's Hospital (GB)
- Harvard University (US)
- Emory University (US)
- Université de Bordeaux (FR)
- Oregon Health & Science University (US)
- Baylor College of Medicine (US)
- Aarhus University Hospital (DK)
- Spanish National Centre for Cardiovascular Research (ES)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Massachusetts General Hospital (US)
- Health Innovations (United States) (US)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Lahey Medical Center (US)
- Duke Medical Center (US)
- Saint Luke's Hospital (US)
- Cytokinetics (United States) (US)
- Instituto Dante Pazzanese de Cardiologia (BR)
- Atlanta VA Medical Center (US)
- Hospital Universitario Virgen del Rocío (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Instituto Cardiovascular de Buenos Aires (AR)
- University College London (GB)
- Friedrich Schiller University Jena (DE)
- University of Colorado Colorado Springs (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1056/nejmoa2504654
- Citations
- 36
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 49.97
Funders
- Cytokinetics