High expression of Mrps10 in diabetic retinopathy: A bioinformatics analysis based on public transcriptomic data

Diabetic retinopathy (DR) is one of the most common microvascular complications in diabetic patients, severely affecting their vision and quality of life. However, the precise molecular mechanisms underlying DR remain unclear. In recent years, mitochondrial ribosomal protein S10 (Mrps10) gene has gained attention due to its high expression, which may be associated with various metabolic disorders. This study aims to explore the expression profile of Mrps10 in diabetic retinopathy and its potential molecular mechanisms. To investigate the expression profile of Mrps10 in DR and explore its potential molecular mechanisms through integrated bioinformatics analysis of public transcriptomic data. We downloaded the diabetic retinopathy dataset GSE111465 from the gene expression omnibus database and used the "limma" package to identify differentially expressed genes. Functional enrichment analysis of differentially expressed genes was conducted through gene ontology analysis, Kyoto encyclopedia of genes and genomes pathway analysis, and metascape enrichment analysis. We also constructed gene modules using weighted gene co-expression network analysis and identified hub genes related to Dr Furthermore, the potential role of Mrps10 in DR was verified using protein-protein interaction networks and the comparative toxicogenomics database. Our study showed that Mrps10 was significantly overexpressed in the retinal tissues of diabetic retinopathy patients. Functional enrichment analysis revealed its association with mitochondrial dysfunction, oxidative stress, and other biological processes. Protein-protein interaction network analysis identified multiple key genes interacting with Mrps10, suggesting its regulatory role in the onset and progression of Dr Comparative toxicogenomics database analysis further supported the hypothesis that high Mrps10 expression is linked to Dr Mrps10 may promote the progression of diabetic retinopathy by regulating mitochondrial function and oxidative stress pathways, indicating its potential as a molecular target for Dr Future research should further investigate the biological functions of Mrps10 and its role in diabetic retinopathy to provide new insights for molecular-targeted therapies for Dr.