Drug-drug interaction between dolutegravir and artemether-lumefantrine in HIV and malaria mono- and co-infections: a pharmacogenetic analysis from Ghana
There is an observed decrease in plasma drug concentrations during the co-administration of artemether-lumefantrine and dolutegravir. Possible long-term effects from non-adherence may include sub-optimal levels that could result in clinical differences and outcomes.
Authors
- Martins Ekor (ORCID: https://orcid.org/0000-0002-4683-0988)
- Robert Peter Biney (ORCID: https://orcid.org/0000-0002-7566-5387)
- Prince Amoah Barnie (ORCID: https://orcid.org/0000-0001-6087-711X)
- Samuel Badu Nyarko (ORCID: https://orcid.org/0000-0003-1104-7544)
- Nicholas Ekow Thomford (ORCID: https://orcid.org/0000-0002-3152-5817)
- Dee Blackhurst (ORCID: https://orcid.org/0000-0002-9899-4634)
- George B. Kyei (ORCID: https://orcid.org/0000-0002-8678-4656)
- Tracy Kellermann (ORCID: https://orcid.org/0000-0003-1542-4976)
- Charné Dixon
- Oksana Ryabinina
- Joel Adu Twum
- John Anyimadu
- Dennis Sappor
Institutions
- University of Cape Coast (GH)
- University of Ghana (GH)
- University of Cape Town (ZA)
- Washington University in St. Louis (US)
- Stellenbosch University (ZA)
- Noguchi Memorial Institute for Medical Research (GH)
Publication Details
- Journal
- AIDS Research and Therapy
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s12981-025-00787-9
- Citations
- 2
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- European Commission
- European and Developing Countries Clinical Trials Partnership