Exploring the causal relationships between spondyloarthritis/ankylosing spondylitis and intervertebral disc degeneration: a bidirectional Mendelian randomization study
SpA/AS significantly increased the risk of IVDD, whereas reverse MR analyses revealed that IVDD increased susceptibility to SpA/AS. Further experimental studies are required to confirm the bidirectional causal relationship between SpA/AS and IVDD.
Authors
- Kexin Qin
- Guangzong Ren
- Xuejun Wang (ORCID: https://orcid.org/0000-0001-9267-1343)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-0820-8805)
- Zunpeng Liu (ORCID: https://orcid.org/0000-0002-8796-7665)
- Xiaochun Yang
Institutions
- Changzhi Medical College (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s13018-025-06222-z
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00