Neuropeptide <scp>Y1</scp> receptor expressing circuit from the central amygdala to lateral hypothalamus modulates binge‐like ethanol consumption in a sex‐dependent manner
Collectively, these results support a model wherein Y1R signaling within the CeA regulates ethanol consumption through circuit-specific mechanisms and broader neuroadaptive changes influenced by sex and individual drinking patterns. This research advances our understanding of the neurobiological mechanisms underlying binge-like ethanol intake and highlights the complex, sex-dependent roles of NPY-Y1R and Y2R signaling in the CeA.
Authors
- Todd E. Thiele (ORCID: https://orcid.org/0000-0001-8908-9256)
- Sophie C. Bendrath (ORCID: https://orcid.org/0000-0002-4423-6598)
- Ashlyn Stone
- Anne M. Dankert (ORCID: https://orcid.org/0000-0002-3046-504X)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1111/acer.70151
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse