SGK1 inhibits oxidative injury and extracellular matrix degradation by activating the GSK-3β (Ser9)/Fyn/NRF2 pathway in pelvic organ prolapse
Our results revealed that SGK1 could potentially slow down the progression of POP under OS by interacting with GSK-3β to promote the GSK-3β (Ser9)/Fyn/NRF2 pathway, which provides a potential therapeutic approach for treating POP.
Authors
- Wei He (ORCID: https://orcid.org/0000-0002-2755-9504)
- Jing Peng
- Zongzhi Yin (ORCID: https://orcid.org/0000-0001-5968-6332)
- Yan Chen (ORCID: https://orcid.org/0000-0001-5325-1151)
- Yunxia Cao (ORCID: https://orcid.org/0000-0002-8715-0874)
- Wei Ye (ORCID: https://orcid.org/0009-0003-7331-8650)
- Yichao Yan (ORCID: https://orcid.org/0000-0003-0429-9452)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1016/j.lfs.2025.123939
- Citations
- 1
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.67