L-5-[11C]-glutamine PET of breast cancer: Preclinical studies in mouse models
Our studies on [<sup>11</sup>C]glutamine in breast cancer models show significant retention of <sup>11</sup>C-activity in the form of [<sup>11</sup>C]glutamate in tumors with high GLS activity that confounds non-invasive inference of GLS activity. This suggests limited utility for [<sup>11</sup>C]glutamine PET for inferring tumor GLS activity and its specific antagonism by drug inhibitors. Our analysis of labeled metabolites in mouse models does, however, yield insights that include the retention of glutamate generated by GLS-mediated catabolism in a large cellular pool and also provide data that is the basis for a compartmental model of glutamine metabolism that is the subject of a companion paper.
Authors
- Christina Dulal
- Austin R. Pantel (ORCID: https://orcid.org/0000-0001-8649-9970)
- Elizabeth Li (ORCID: https://orcid.org/0000-0001-5961-2894)
- Prashanth K. Padakanti
- Jianbo Cao (ORCID: https://orcid.org/0000-0002-0859-1680)
- Rong Zhou (ORCID: https://orcid.org/0000-0003-4018-381X)
- David A. Mankoff (ORCID: https://orcid.org/0000-0002-6971-5413)
- Raheema Damani (ORCID: https://orcid.org/0000-0001-7587-2442)
- Hsiaoju S. Lee (ORCID: https://orcid.org/0000-0001-9082-8618)
- Hoon Choi (ORCID: https://orcid.org/0000-0003-0064-5290)
- Shihong Li
- Christopher T. Hensley (ORCID: https://orcid.org/0000-0001-6895-4001)
Institutions
- University of Cambridge (GB)
- Cancer Research UK (GB)
- University of Alabama at Birmingham (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1016/j.nucmedbio.2025.109092
- Citations
- 1
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36