Cerebrospinal fluid catecholamines levels in Alzheimer’s disease, frontotemporal dementia, and normal controls
This is the first study reporting lower CSF L-DOPA levels in AD. Similar norepinephrine levels despite locus coeruleus neurons loss in AD point to compensatory mechanisms that could exacerbate L-DOPA deficiency.
Authors
- Joana Guimarães (ORCID: https://orcid.org/0000-0003-1540-1395)
- María José Sá (ORCID: https://orcid.org/0000-0003-0825-2977)
- Paula Serrão (ORCID: https://orcid.org/0000-0002-3663-7500)
- Lucinda Sequeira
- Maria Augusta Vieira‐Coelho (ORCID: https://orcid.org/0000-0001-8968-1348)
- Isabel Moreira (ORCID: https://orcid.org/0000-0002-0233-5416)
Institutions
- Fernando Pessoa University (PT)
- Universidade do Porto (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Instituto de Saúde (BR)
- Istituto di Farmacologia Traslazionale (IT)
Publication Details
- Journal
- Neurodegenerative Disease Management
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1080/17582024.2025.2554527
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00