Association of plasma Alzheimer's disease biomarkers with cognitive decline in cognitively unimpaired individuals
Mass-spectrometry-based plasma phosphorylated tau217 was associated with cognitively unimpaired to mild cognitive impairment (MCI) progression. Plasma amyloid beta 42/40 was a significant predictor in BioFINDER but not the Mayo Clinic Study of Aging (MCSA). Amyloid positron emission tomography (PET) was the strongest predictor of progression to MCI in the MCSA. Plasma had added value to amyloid PET in BioFINDER but not the MCSA. Biomarker performance may vary with cohort and biomarker measurement differences.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Philip B. Verghese (ORCID: https://orcid.org/0000-0003-4793-564X)
- Petrice M. Cogswell (ORCID: https://orcid.org/0000-0002-8128-4476)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Terry M. Therneau (ORCID: https://orcid.org/0000-0003-1490-6711)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Tim West (ORCID: https://orcid.org/0000-0003-3267-8249)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Joel B. Braunstein (ORCID: https://orcid.org/0000-0002-1155-0206)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Nicolas R. Barthélemy (ORCID: https://orcid.org/0000-0003-4937-2860)
- Michael Griswold (ORCID: https://orcid.org/0000-0001-8106-5516)
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Mayo Clinic (US)
- Lund University (SE)
- Washington University in St. Louis (US)
- WinnMed (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- C2N Diagnostics (United States) (US)
- Skåne University Hospital (SE)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1002/alz.70625
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Alzheimer's Association
- Cure Alzheimer's Fund
- Australian Government
- GHR Foundation
- Rainwater Charitable Foundation
- Lunds Universitet
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Skånes universitetssjukhus
- National Institutes of Health
- Parkinsonfonden
- European Research Council
- National Institute on Aging