The Advantages of The Alpha-Glycosylated Form of Hesperidin, Increased Bioavailability and Beneficial Effects for Human Health

Hesperidin is a bioflavonoid found in high concentrations in citrus fruits.It benefits cardiovascular function, type II diabetes, anti-inflammation, and cutaneous functions, including wound healing, UV protection, anti-inflammation, antimicrobial, anti-skin cancer, and skin lightening.It has low water solubility and poor oral bioavailability.To improve its solubility and bioavailability, Alpha-Glucosyl Hesperidin (AGH) has been synthesized from hesperidin by transglucosylase using cyclodextrin glucotransferase.It is 10,000more soluble and has 3.7higher bioavailability than hesperidin.AGH has various pharmacological effects, such as hypolipidemic and hypouricemic effects, and may therefore be a useful supplement or drug for people who are fighting with obesity and fat loss.In this review we summarize the potential benefits of alpha-glucosyl hesperidin and add points for safety and hesperidin use from a commercial point of view.