The contributions of aquaporin‐4 to water exchange across the blood–brain barrier measured by filter‐exchange imaging
WEX<sub>BBB</sub> decreased by 32% after administering TGN-020, but no downward trend was noted after administering ouabain. Our findings indicate that AQP4 expression/function, but not NKA activity on the luminal side of endothelial cells, plays a significant role in regulating WEX<sub>BBB</sub>.
Authors
- Zejun Wang (ORCID: https://orcid.org/0000-0003-4657-8812)
- Bingjie Jiao
- Ke-Yu Lu (ORCID: https://orcid.org/0000-0003-0124-4309)
- Linghui Zeng
- W. Li
- Ruiliang Bai (ORCID: https://orcid.org/0000-0003-4246-5984)
- Shuyuan Tan
- Lili Zhang (ORCID: https://orcid.org/0009-0009-6981-6167)
- Qingcheng Li
- Xuetao Wu
Institutions
- Allen Institute for Brain Science (US)
- Chinese Academy of Sciences (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Institute of Cognitive and Brain Sciences (US)
- Institute of Biophysics (CN)
- Chinese Institute for Brain Research (CN)
- University of Chinese Academy of Sciences (CN)
- Hangzhou City University
- Zhejiang University (CN)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1002/mrm.70049
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China