SRT1720 ameliorates LPS-induced depressive-like behaviors in mice and activates Parkin-mediated mitophagy
These findings suggested that activation of SIRT1 could alleviate depressive-like behaviors in mice following LPS challenge, potentially through a Parkin-dependent mitophagy mechanism.
Authors
- Lingling Wu (ORCID: https://orcid.org/0000-0001-6466-8569)
- Shunlun Wan
- Wenfeng Zeng (ORCID: https://orcid.org/0000-0002-0385-6475)
- Yunxia Wang (ORCID: https://orcid.org/0000-0002-5103-955X)
- Chaoran Li (ORCID: https://orcid.org/0000-0001-9517-8431)
- Jianli Shi
- Luna Sun
Institutions
- Naval University of Engineering (CN)
- People's Liberation Army 401 Hospital (CN)
- Sanya Central Hospital (CN)
- Chinese People's Liberation Army Navy Hospital of Guangzhou (CN)
Publication Details
- Journal
- BMC Neuroscience
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s12868-025-00968-2
- Citations
- 2
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- National Natural Science Foundation of China