Cerebrospinal fluid leptin in Alzheimer’s disease: relationship to plasma levels and to cerebrospinal amyloid
CSF leptin levels strongly correlate with plasma leptin and are reduced in individuals with AD biomarker positivity. This suggests plasma leptin may reflect central leptin activity. Our findings support a link between leptin signaling and amyloid deposition in AD.
Authors
- Claire Hourrègue
- Emmanuel Cognat (ORCID: https://orcid.org/0000-0002-3521-5832)
- Élodie Bouaziz-Amar (ORCID: https://orcid.org/0000-0003-0880-5826)
- Matthieu Lilamand (ORCID: https://orcid.org/0000-0002-4622-2413)
- Jacques Hugon (ORCID: https://orcid.org/0000-0002-1848-8628)
- Julien Dumurgier (ORCID: https://orcid.org/0000-0003-2070-9706)
- François Mouton‐Liger (ORCID: https://orcid.org/0000-0001-8172-6548)
- Agathe Vrillon (ORCID: https://orcid.org/0000-0002-0761-7885)
- Fidaa Ibrahim
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Matthieu Martinet
- Jeanne Neez
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Fernand-Widal (FR)
- Hôpital Lariboisière (FR)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1515/cclm-2025-0304
- Citations
- 3
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- Institut National de la Santé et de la Recherche Médicale