Mechanisms of IGF1R signaling in type 2 diabetes-related neurodegeneration and therapeutic implications of exercise
IGF1R is pivotal in regulating neuroinflammation and neuronal apoptosis in T2D-associated neurodegeneration. Combined TCM and structured exercise may beneficially modulate IGF1R-dependent signaling and protect neurons. Further clinical studies are needed to validate these findings and assess their therapeutic potential.
Authors
- Ming Gong (ORCID: https://orcid.org/0000-0002-3554-7378)
- Canhong Yang (ORCID: https://orcid.org/0000-0003-0354-2334)
- Xinyue Sun (ORCID: https://orcid.org/0000-0002-0778-0412)
- Zhongqi Mao
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Jinan University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-30
- DOI
- https://doi.org/10.1186/s40001-025-03087-0
- Citations
- 3
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Guangzhou Municipal Science and Technology Project