Experience and safety of intraoperative Neuropixels: a case series of 56 patients
Intraoperative Neuropixels recordings can be done safely for large-scale neuronal recordings. Over time, the authors experienced no probe fractures and improved success rate of microelectrode recording. Further measures to float the electrodes, limit forces on the probe, and prevent probe fracture during insertion may improve the yield. Neuropixels has tremendous potential for future applications in clinical functional mapping over traditional microelectrodes.
Authors
- Cathryn R. Cadwell (ORCID: https://orcid.org/0000-0003-1963-8285)
- Kristin K. Sellers (ORCID: https://orcid.org/0000-0002-0517-2296)
- John P. Andrews (ORCID: https://orcid.org/0000-0002-8025-1525)
- Marleen Welkenhuysen (ORCID: https://orcid.org/0000-0001-6729-9391)
- Matthew K. Leonard (ORCID: https://orcid.org/0000-0002-8530-880X)
- Duo Xu (ORCID: https://orcid.org/0000-0002-8259-8688)
- Jason E. Chung (ORCID: https://orcid.org/0000-0002-1591-584X)
- B. Dutta
- Edward F. Chang (ORCID: https://orcid.org/0000-0003-2480-4700)
- Quinn Greicius (ORCID: https://orcid.org/0000-0002-3899-9855)
- Tanay Poddar
Institutions
- University of California, San Francisco (US)
- IMEC (BE)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3171/2025.4.jns241162
- Citations
- 1
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.91