Phase I Dose-Escalation Trial Combining Olaparib and Thoracic Radiotherapy in Extensive-Stage Small Cell Lung Cancer

This study established the MTD and recommended a phase II dose of olaparib at 200 mg twice daily with concurrent low-dose TRT, and the combination seemed safe without unexpected toxicities.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-08-29
DOI
https://doi.org/10.1158/1078-0432.ccr-24-4342
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
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article

Phase I Dose-Escalation Trial Combining Olaparib and Thoracic Radiotherapy in Extensive-Stage Small Cell Lung Cancer

Robert Michael Daly, Michael David Offin, Benjamin H. Lok, Michelle S. Ginsberg et al.
1 links
Clinical Cancer Research
Lung Cancer Research Studies
article

Phase I Dose-Escalation Trial Combining Olaparib and Thoracic Radiotherapy in Extensive-Stage Small Cell Lung Cancer

Robert Michael Daly, Michael David Offin, Benjamin H. Lok, Michelle S. Ginsberg, Daphna Y. Gelblum, Helena A. Yu, Rupesh Kotecha, Narek Shaverdian, Abraham J. Wu, Vanessa J. Ng, Jacob Y. Shin, Quincey LaPlant, Charles M. Rudin, Andreas Rimner, Charles B. Simone, Annemarie Fernandes Shepherd, Zhigang Zhang, Ellen Yorke, Alina Ionescu
article en

Abstract

This study established the MTD and recommended a phase II dose of olaparib at 200 mg twice daily with concurrent low-dose TRT, and the combination seemed safe without unexpected toxicities.

Clinical Cancer ResearchVol. 31(22)
Baptist Hospital of Miami (US), Memorial Sloan Kettering Cancer Center (US), University of Freiburg (DE), University of Washington (US), Princess Margaret Cancer Centre (CA), Baptist Health South Florida (US), New York Proton Center (US), Seattle University (US)
Openalex Percentile: Top 68%
Lung Cancer Research Studies
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