Why do People with Heart Failure Die? Rationale and Design of the RHYTHM-HF Study
The RHYTHM-HF study is a contemporary natural history study which investigated causes and mechanisms of death in patients with heart failure. It is the largest study to report terminal rhythm data in patients with heart failure, the largest contemporary prospective autopsy study in heart failure, and the only study to describe the interaction between terminal rhythm and pathological cause of death using modern adjudication standards. We anticipate new mechanistic insights into the cause and mode of death in heart failure. These findings will generate hypotheses for future clinical research into reducing death in heart failure.
Authors
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Theresa A. McDonagh (ORCID: https://orcid.org/0000-0003-1305-9602)
- Roy S. Gardner (ORCID: https://orcid.org/0000-0002-6792-6671)
- Gary A. Wright
- Iain Squire (ORCID: https://orcid.org/0000-0002-6282-4318)
- Sylvia Wright (ORCID: https://orcid.org/0000-0002-0810-3915)
- Chunlan Jiang (ORCID: https://orcid.org/0000-0002-6607-4710)
- Simon A. S. Beggs (ORCID: https://orcid.org/0000-0003-0708-9151)
- Kyungmoo Ryu
- Luke C. McSpadden
- Derek T. Connelly
Institutions
- King's College - North Carolina (US)
- Danaher (United States) (US)
- Abbott (Sweden) (SE)
- Glenfield Hospital (GB)
- Golden Jubilee National Hospital (GB)
- Abbott (United States) (US)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- King's College Hospital (GB)
- Queen Elizabeth University Hospital (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1002/ejhf.70014
- Citations
- 1
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 1.39