c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation
These findings unveil NVP as a promising host-directed agent that simultaneously limits viral propagation and reduces inflammation, and suggest repurposing NVP as a broad-spectrum antiviral.
Authors
- Fuping You
- Yunfei Xie (ORCID: https://orcid.org/0000-0002-2758-9236)
- Haocheng Wang (ORCID: https://orcid.org/0000-0002-5033-0230)
- Hongli Jia (ORCID: https://orcid.org/0000-0002-5606-1895)
- T Liu (ORCID: https://orcid.org/0000-0003-1635-2986)
- Xuefei Guo (ORCID: https://orcid.org/0000-0002-9590-8235)
- Yang Zhao (ORCID: https://orcid.org/0000-0001-6521-1851)
- Xingyu Chen (ORCID: https://orcid.org/0000-0002-9284-4950)
- Yang Li (ORCID: https://orcid.org/0000-0002-2009-7079)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-1827-4427)
Institutions
- China Pharmaceutical University (CN)
- Peking University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1651730
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78