Stretch‐Induced Increase in Ca <sup>2+</sup> ‐Spark Rate in Rabbit Atrial Cardiomyocytes Requires TRPA1 and Intact Microtubule Network
In atrial cardiomyocytes, diastolic stretch enhances Ca<sup>2+</sup>-spark rate through a mechanism that requires microtubular integrity and TRPA1 but that is independent of redox signaling. TRPA1 emerges as a key regulator of stretch-induced Ca<sup>2+</sup> handling in atrial cells, with potential implications for arrhythmogenesis.
Authors
- Rémi Peyronnet (ORCID: https://orcid.org/0000-0002-5708-6410)
- Teresa Schiatti
- Gudrun Antoons (ORCID: https://orcid.org/0000-0002-5846-0363)
- Breanne A. Cameron (ORCID: https://orcid.org/0000-0003-0334-1217)
- Marion Kuiper
- Josef Madl (ORCID: https://orcid.org/0000-0003-3637-2546)
- Anna‐Sophia Kittel (ORCID: https://orcid.org/0009-0008-5138-7272)
- Patrick Schönleitner
- Ulrich Schotten (ORCID: https://orcid.org/0000-0003-1532-3315)
- Ana Simón-Chica (ORCID: https://orcid.org/0000-0002-0664-0397)
- Peter Karl Kohl (ORCID: https://orcid.org/0000-0003-0416-6270)
- Eva A. Rog‐Zielinska (ORCID: https://orcid.org/0000-0002-3295-4728)
- Clemens Kreutz (ORCID: https://orcid.org/0000-0002-8796-5766)
- David Filgueiras‐Rama
- Winfried Römer (ORCID: https://orcid.org/0000-0002-2847-246X)
- Ursula Ravens (ORCID: https://orcid.org/0000-0003-3813-3127)
- J. Fu (ORCID: https://orcid.org/0009-0001-4999-7249)
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Cardiovascular Institute Hospital (JP)
- Maastricht University (NL)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro de Investigación Biomédica en Red (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1161/jaha.124.040495
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- China Scholarship Council