The relationship between histopathological data and molecular alterations with oncological outcomes in endometrioid-type endometrial cancers and a novel POLE mutation
POLE mutations were linked to the most favorable molecular prognostic factor. NSMP cases showed the longest DFS and OS, while p53-mut had the shortest OS. Except for POLE, molecular features alone were insufficient for establishing risk groups, highlighting the continued importance of histopathology in EEC management.
Authors
- Elif Akşahin (ORCID: https://orcid.org/0000-0002-6982-6324)
- Başak Özge Kayan (ORCID: https://orcid.org/0000-0003-0699-0482)
- Yeliz Aykanat (ORCID: https://orcid.org/0000-0001-6550-2456)
- İsmail Yılmaz (ORCID: https://orcid.org/0000-0003-2163-1795)
- Sait Şükrü Çebi (ORCID: https://orcid.org/0000-0002-9152-8227)
- Şennur İlvan (ORCID: https://orcid.org/0000-0002-6746-6599)
- Macit Arvas (ORCID: https://orcid.org/0000-0003-2548-1667)
- Tugan Beşe (ORCID: https://orcid.org/0000-0003-4866-1695)
- Ömer Uysal (ORCID: https://orcid.org/0000-0002-8833-697X)
- Abdullah Serdar Açıkgöz (ORCID: https://orcid.org/0000-0001-9355-7753)
- Fuat Demirkıran (ORCID: https://orcid.org/0000-0002-0439-2502)
- Ayse Namal
Institutions
- University of Health Sciences Lahore (PK)
- Istanbul University-Cerrahpaşa (TR)
- Sağlık Bilimleri Üniversitesi (TR)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3802/jgo.2026.37.e6
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Istanbul Üniversitesi-Cerrahpasa