Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
CDH6 expression is elevated in RA FLS due to epigenetic and local conditions of synovitis promoting migration, survival and cell growth, which are characteristic features of aggressive RA FLS. The intracellular distribution suggests additional functions beyond adhesion and homotypic aggregation, such as signaling and gene regulation. These data suggest CDH6 contributes to RA pathogenesis by influencing pathologic FLS behavior and could be a therapeutic target.
Authors
- Eunice Choi (ORCID: https://orcid.org/0009-0006-4700-6452)
- Robert J. Benschop (ORCID: https://orcid.org/0000-0001-6313-5218)
- David L. Boyle (ORCID: https://orcid.org/0000-0002-1454-2834)
- Gary S. Firestein (ORCID: https://orcid.org/0000-0003-3495-960X)
- Gregory R. Dressler (ORCID: https://orcid.org/0000-0002-7967-6104)
- Camilla Ribeiro Lima Machado (ORCID: https://orcid.org/0000-0001-6584-195X)
- Wei Wang (ORCID: https://orcid.org/0000-0002-3422-0402)
- Narayanan B. Perumal
Institutions
- University of San Diego (US)
- Eli Lilly (United States) (US)
- University of Michigan (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- Inflammation Research Foundation (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s13075-025-03637-1
- Citations
- 3
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 4.87
Funders
- Eli Lilly and Company
- University of California, San Diego