Effects of dermal-fibroblast-derived ECM and dextran sulfate supplementation on osteoblast differentiation – results of a preliminary in vitro study

The addition of Dx-S in autologous fibroblast-derived ECM induces an improvement in osteoinductivity. Addition of Dx-S may therefore be a useful adjunct in the in vitro bone generation models. Whether these results may represent a piece in the puzzle for difficult healing situations in patients with nonunions and bone defects should be subject to further study.