Exercise training improves metabolic and circulatory function in COPD patients with NAFLD: evidence from clinical and molecular profiling
Our preliminary findings suggest that exercise training may offer unique benefits for patients with comorbid COPD and NAFLD, particularly by enhancing metabolic efficiency and circulatory function. EGR1 may serve as a potential biomarker for exercise responsiveness in this population, reflecting underlying immunomodulatory mechanisms. This insight may also aid in distinguishing COPD subtypes and tailoring exercise-based therapeutic strategies.
Authors
- Yi Ding (ORCID: https://orcid.org/0000-0002-2158-3108)
- Shijing Jia (ORCID: https://orcid.org/0000-0002-3467-8149)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Panpan Liu (ORCID: https://orcid.org/0000-0002-7447-7026)
- Cuiling Zhu
- Yi-cai Qian
- Xiaoxiang Liu
Institutions
- Tongji University (CN)
- Second Military Medical University (CN)
- The First People's Hospital of Changde (CN)
- Anhui Provincial Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fmed.2025.1660072
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China