Toxicological analysis of metabolites in ischemic stroke based on salivary metabolomics
A panoramic analysis framework of salivary metabolomics in ischemic stroke was constructed, and the cascade disorder of the amino acid-lipid-nucleotide metabolic network was elucidated. The screened core metabolite markers and their regulatory pathways not only provide highly specific tools for early diagnosis of stroke, but also provide research basis for the development of innovative therapies based on metabolic microenvironment regulation.
Authors
- Hua Li (ORCID: https://orcid.org/0000-0001-9644-6768)
- Wang‐Hua Liu
- Yicheng Liu (ORCID: https://orcid.org/0000-0003-3571-3839)
- Shu-Yue Fu
- Shuang Zhang (ORCID: https://orcid.org/0000-0002-6177-8137)
- Jie Liu (ORCID: https://orcid.org/0000-0003-3307-1975)
- Yansong Liu (ORCID: https://orcid.org/0000-0002-9618-5243)
- Yijia Xu
- Yun Long (ORCID: https://orcid.org/0000-0003-0274-8322)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Rome Foundation (US)
- Department of Science and Technology of Hunan Province (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fmolb.2025.1609227
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hunan Province