Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments
Our findings suggest that the high expression of eight autophagy and pyroptosis-related genes in OSCC correlates with poor prognosis. In particular, BAK1 emerges as an independent prognostic marker with high diagnostic potential. These results offer promising insights into the development of gene-targeted therapies for OSCC, with BAK1 representing a potential therapeutic target.
Authors
- Xiaoyu Song (ORCID: https://orcid.org/0000-0002-6606-327X)
- L Qiao
- Blinov Si
- Jing Xiao (ORCID: https://orcid.org/0000-0002-6525-252X)
Institutions
- Harbin Medical University (CN)
- Jilin University (CN)
- Harbin Institute of Technology (CN)
- Changchun University (CN)
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fonc.2025.1645670
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52