Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments

Our findings suggest that the high expression of eight autophagy and pyroptosis-related genes in OSCC correlates with poor prognosis. In particular, BAK1 emerges as an independent prognostic marker with high diagnostic potential. These results offer promising insights into the development of gene-targeted therapies for OSCC, with BAK1 representing a potential therapeutic target.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-29
DOI
https://doi.org/10.3389/fonc.2025.1645670
Citations
1
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
1.52
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article

Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments

Xiaoyu Song, L Qiao, Blinov Si, Jing Xiao
1 citations
Frontiers in Oncology
Ferroptosis and cancer prognosis
1.52
article

Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments

Xiaoyu Song, L Qiao, Blinov Si, Jing Xiao
article en
1 citations

Abstract

Our findings suggest that the high expression of eight autophagy and pyroptosis-related genes in OSCC correlates with poor prognosis. In particular, BAK1 emerges as an independent prognostic marker with high diagnostic potential. These results offer promising insights into the development of gene-targeted therapies for OSCC, with BAK1 representing a potential therapeutic target.

Frontiers in OncologyVol. 15
Harbin Medical University (CN), Jilin University (CN), Harbin Institute of Technology (CN), Changchun University (CN), Michigan State University (US)
Openalex Percentile: Top 15%
Ferroptosis and cancer prognosis
1.52
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