High-fat diet-induced dyslipidemia drives retinal ECE-1 and ET-1 upregulation
Our findings provide compelling evidence that HFD-induced dyslipidemia is associated with retinal inflammation and endothelial dysfunction, with ECE-1 and ET-1 serving as key mediators. These results highlight a potential therapeutic target for preventing retinal complications associated with metabolic disorders.
Authors
- Huilan Zhang (ORCID: https://orcid.org/0000-0002-2366-7321)
- Jing Chen (ORCID: https://orcid.org/0000-0001-5972-3623)
- Longli Zhang (ORCID: https://orcid.org/0000-0001-8728-0321)
- Chunyan Shan (ORCID: https://orcid.org/0000-0003-0085-667X)
- Yi Hou
- Yanhui Yang (ORCID: https://orcid.org/0000-0003-3896-916X)
- Shuo Sun (ORCID: https://orcid.org/0009-0000-6590-9184)
- Kaiwen Hei
Institutions
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fendo.2025.1640890
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00