Integrative transcriptomic and machine learning analyses identify HDAC9 as a key regulator of mitochondrial dysfunction and senescence-associated inflammation in diabetic nephropathy
Mitochondrial dysfunction and senescence-associated inflammation contribute to DN progression. The five identified hub genes demonstrate strong diagnostic potential, and HDAC9 is likely to be a potential therapeutic target for reducing mitochondrial injury, senescence, and inflammation in DN.
Authors
- Chun‐Po Steve Fan (ORCID: https://orcid.org/0000-0002-1278-0118)
- Guanglin Yang (ORCID: https://orcid.org/0000-0002-0121-1059)
- Dong Pang (ORCID: https://orcid.org/0000-0002-0448-9128)
- Jinji Chen
- Jing Huang (ORCID: https://orcid.org/0009-0002-7218-9845)
- Shaohua Chen (ORCID: https://orcid.org/0000-0003-1871-9219)
Institutions
- Guangxi Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1627173
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Guangxi Medical University
- Division of Graduate Education