A case report of TBL1XR1-RARB positive pediatric acute promyelocytic leukemia and literature review
This study underscores the molecular heterogeneity and distinct clinical course of TBL1XR1-RARB-positive vAPL. It highlights significant therapeutic challenges, including a high rate of primary resistance and relapse, and provides critical guidance for the management of this rare but clinically significant disease.
Authors
- Ruifang Zeng (ORCID: https://orcid.org/0000-0001-6657-1330)
- Chunyan Du (ORCID: https://orcid.org/0000-0002-6923-015X)
- Fu Liu (ORCID: https://orcid.org/0000-0003-0041-1873)
- Jingyi Fan (ORCID: https://orcid.org/0000-0002-4624-5287)
- Tao Hu (ORCID: https://orcid.org/0000-0002-9728-186X)
- Linlin Huang (ORCID: https://orcid.org/0000-0003-0788-9773)
Institutions
- Mianyang Central Hospital (CN)
- Kingmed Diagnostics (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.3389/fonc.2025.1566404
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00