Integrated single-cell and clinical transcriptomic analysis identifies blunted glycolytic activation as a hallmark of maladaptive repair in renal ischemia–reperfusion
Although causality is unproven, early glycolytic activation appears linked to regenerative repair. Glycolysis thus emerges as both a biomarker of epithelial fate and a potential therapeutic target to limit CKD progression.
Authors
- Hervé Quintard (ORCID: https://orcid.org/0000-0002-3870-6370)
- Maarten Naesens (ORCID: https://orcid.org/0000-0002-5625-0792)
- Andrew Torck
- Frédéric Sangla
- David Legouis (ORCID: https://orcid.org/0000-0002-2924-9737)
Institutions
- University of Geneva (CH)
- University of Fribourg (CH)
- Fribourg Development Agency (CH)
- University Hospital of Geneva (CH)
- Geneva College (US)
- KU Leuven (BE)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1080/0886022x.2025.2549400
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hôpitaux Universitaires de Genève