Bacillus velezensis MZ09 alleviates DSS-induced colitis in piglets by remodeling the intestinal microbiota activating the SCFAs–GPR43–STAT3 pathway and suppressing NLRP3 inflammasome-mediated pyroptosis
B. velezensis MZ09 alleviates DSS-induced colitis in piglets through multiple pathways, including gut microbiota remodeling, SCFAs-GPR43-STAT3 axis activation, and NLRP3 inflammasome-mediated pyroptosis suppression. These findings provide a new theoretical basis for the development of targeted intervention strategies for IBD, suggesting that MZ09 represents a potentially promising therapeutic agent for IBD treatment.
Authors
- Xuechen Huo
- Zhihua Yu (ORCID: https://orcid.org/0000-0003-4993-0199)
- Xiuyu Fang (ORCID: https://orcid.org/0009-0007-5862-814X)
- Baoming Shi (ORCID: https://orcid.org/0000-0001-8560-4564)
- Zhengyi Wang (ORCID: https://orcid.org/0000-0001-8609-480X)
- Yongqing Du
- Haiyang Liu (ORCID: https://orcid.org/0000-0001-6332-6751)
Institutions
- Northeast Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s40104-025-01262-1
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China