Unveiling the hidden impact: metabolomic changes in children undergoing VSD repair
The perioperative metabolic profiles in children undergoing VSD repair under CPB were significantly altered, presumably because of the inflammatory response and endothelial cell dysfunction induced by CPB. Molecular docking predictions suggested that bosentan and AdipoRon may be potent compounds that influence perioperative damage.
Authors
- Hailing Tu
- Junkai Duan (ORCID: https://orcid.org/0000-0002-6515-6626)
- Yangyang Wu (ORCID: https://orcid.org/0000-0003-4606-1741)
- Yong Zou (ORCID: https://orcid.org/0009-0007-3897-0087)
- Jiyi Huang (ORCID: https://orcid.org/0000-0001-8496-2087)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial Children's Hospital (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1186/s12887-025-06083-9
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Jiangxi Province