Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction
Compound 11a is a promising thiadiazole-based candidate with notable in vitro potency, selectivity, and mechanistic activity, supporting its potential for further pharmacokinetics/toxicity evaluation and structural refinement as a VEGFR-2-targeted agent.
Authors
- Ibrahim H. Eissa (ORCID: https://orcid.org/0000-0002-6955-2263)
- Aisha A. Alsfouk (ORCID: https://orcid.org/0000-0003-4497-5013)
- Walid E. Elgammal (ORCID: https://orcid.org/0000-0002-5982-5635)
- Hazem Elkady (ORCID: https://orcid.org/0000-0003-0893-6703)
- Omar Soliman (ORCID: https://orcid.org/0000-0003-0488-7385)
- Eslam B. Elkaeed (ORCID: https://orcid.org/0000-0002-2546-8035)
- Mariam Omara
- Dalal Z. Husein (ORCID: https://orcid.org/0000-0001-7552-0914)
- Hazem A. Mahdy
- Ahmed M. Metwaly (ORCID: https://orcid.org/0000-0001-8566-1980)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Alfaisal University (SA)
- Nile Valley University (SD)
- Al-Azhar University (EG)
- South Valley University (EG)
- University Teaching Hospital (ZM)
- Al-Azhar University (ID)
- New Valley University
- Almaarefa University
- Alexandria University (EG)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1080/17568919.2025.2552639
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- AlMaarefa University
- Princess Nourah Bint Abdulrahman University