Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An <scp>EAACI AllergoOncology</scp> Scoping Review

AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology.

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Publication Details

Journal
Allergy
Published
2025-08-29
DOI
https://doi.org/10.1111/all.16672
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00

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Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review

Leticia de las Vecillas, Verena Pick, Tomás Chivato, Aurélie Poli et al.
Allergy
Immune cells in cancer
article

Molecular Signatures and Functional Pathways of Human Monocytes and Macrophages in Allergy: An EAACI AllergoOncology Scoping Review

Leticia de las Vecillas, Verena Pick, Tomás Chivato, Aurélie Poli, Milena Sokołowska, Gabriel Osborn, María Isabel Delgado Dolset, Mariona Pascal, Leticia Martín‐Cruz, Óscar Palomares, Alessandro Michelucci, Heather J. Bax, Rodolfo Bianchini, Urszula Radzikowska, Jitesh Chauhan, Luigi Cari, Carmela Pablo‐Torres, José Basílio, Sophia N. Karagiannis, Rebecca Adams, Giuseppe Nocentini, Hanna Mayerhofer, Isabel Adoración Martín‐Antoniano, María Marta Escribese, Nataliya Rohr‐Udilova, Elena Izquierdo, Erika Jensen‐Jarolim, Andrea Escolar‐Peña, Christoph Bergmann, R. R. Rios, Melanie Grandits
article en

Abstract

AllergoOncology explores the intersection of allergic diseases and cancer, focusing on shared immune mechanisms. While monocytes and macrophages are extensively studied in cancer, their roles in allergic diseases remain underexplored. To address this gap, we conducted a scoping review to systematically characterize the molecular landscape and related pathways of human monocytes and macrophages in allergy. An automated search of PubMed and Web of Science databases retrieved 4668 unique articles, which were manually curated based on predefined inclusion and exclusion criteria, yielding 138 eligible studies. From these, we identified 451 molecules associated with monocyte and macrophage responses across allergic disorders. Data analyses revealed a research bias towards blood-derived monocytes, underrepresentation of tissue-resident macrophages, and limited inclusion of miRNAs. Semantic similarity and pathway enrichment analyses highlighted a common molecular signature across major allergic disorders, with consistent enrichment in interleukin signaling and immune activation pathways. To enhance reproducibility and translational utility for researchers and clinicians, we developed ALO•HA, a web application for interactive data exploration. This overview of monocyte and macrophage molecular responses in human allergy underscores the need for integrative, human-focused approaches to better define their roles, and to guide future therapeutic strategies in allergic diseases and at the interface with oncology.

AllergyVol. 80(10)
Universidad San Pablo CEU (ES), Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento (PT), Universidad Complutense de Madrid (ES), Harvard University (US), University of Lisbon (PT), University of Veterinary Medicine Vienna (AT), King's College London (GB), University of Zurich (CH), University of Perugia (IT), Breast Cancer Now (GB), Düsseldorf University Hospital (DE), Spanish National Cancer Research Centre (ES), Integrated Oncology (United States) (US), Luxembourg Institute of Health (LU), Hospital Clínic de Barcelona (ES), CK-CARE (CH), Verbund Katholischer Kliniken Düsseldorf (DE), Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE), University and Rehabilitation Clinics Ulm (DE), University Hospital Cologne (DE), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Heinrich Heine University Düsseldorf (DE), Universitat de Barcelona (ES), Medical University of Vienna (AT)
European Academy of Allergy and Clinical Immunology
Openalex Percentile: Top 76%
Immune cells in cancer
DOIOpen Access PDFOpenAlex
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