Unusual bone marrow metastasis revealed by recurrent haematuria

Bone marrow metastasis of solid tumours is a sign of advanced disease, with their frequency depending on the primary cancer site. Bone marrow metastasis of bladder cancer is an unusual presentation of the disease. We present a case of a patient with non-muscle-invasive bladder cancer, presenting with recurrent macroscopic haematuria after urinary catheterisation leading to discovery of bi-cytopenia on complete blood count. Myelogram realized after sternal bone marrow aspiration showed presence of metastatic cells immunostained for urothelial nature. The clinical course was rapidly unfavorable leading to patient's death shortly after diagnosis. metastasis of bladder cancer to the bone marrow is a highly unusual situation associated with a poor prognosis.

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Journal
Annales de biologie clinique
Published
2025-08-29
DOI
https://doi.org/10.1684/abc.2025.1991
Primary Topic
Hematological disorders and diagnostics
Type
article
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article

Unusual bone marrow metastasis revealed by recurrent haematuria

Virginie Verkarre, François Audenet, Luc Darnige, Nadia Rivet et al.
Annales de biologie clinique
Hematological disorders and diagnostics
article

Unusual bone marrow metastasis revealed by recurrent haematuria

Virginie Verkarre, François Audenet, Luc Darnige, Nadia Rivet, Laure Gibault, Hatem Gabsi
article en

Abstract

Bone marrow metastasis of solid tumours is a sign of advanced disease, with their frequency depending on the primary cancer site. Bone marrow metastasis of bladder cancer is an unusual presentation of the disease. We present a case of a patient with non-muscle-invasive bladder cancer, presenting with recurrent macroscopic haematuria after urinary catheterisation leading to discovery of bi-cytopenia on complete blood count. Myelogram realized after sternal bone marrow aspiration showed presence of metastatic cells immunostained for urothelial nature. The clinical course was rapidly unfavorable leading to patient's death shortly after diagnosis. metastasis of bladder cancer to the bone marrow is a highly unusual situation associated with a poor prognosis.

Annales de biologie cliniqueVol. 83(5)
Assistance Publique – Hôpitaux de Paris (FR), Hôpital Européen (FR)
Zero hunger
Openalex Percentile: Top 66%
Hematological disorders and diagnostics
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Unusual bone marrow metastasis revealed by recurrent haematuria — Virginie Verkarre, François Audenet, et al. · Annales de biologie clinique (2025) | TGRS Research Map | TGRS