Impact of Age and Sex on Coronary Flow Reserve and Microvascular Function in Patients With Angina and Nonobstructive Coronary Arteries
Increasing age was associated with a decrease in coronary microvascular function and increase in microcirculatory resistance, which was pronounced in women but not in men. There was no association of baseline Tmn with age, suggesting that age-related impairment in CFR was primarily driven by reduced hyperemic flow.
Authors
- Natalija Odanović (ORCID: https://orcid.org/0000-0003-0343-6195)
- Natasha Cigarroa (ORCID: https://orcid.org/0009-0005-5013-348X)
- Spyridon Kostantinis (ORCID: https://orcid.org/0000-0003-1099-681X)
- Steffne Kunnirickal (ORCID: https://orcid.org/0000-0002-9412-3145)
- Samit Shah (ORCID: https://orcid.org/0000-0002-3664-4102)
- Nida Latif (ORCID: https://orcid.org/0000-0002-2198-5190)
- Gabriel Garcia Castro
Institutions
- Yale University (US)
- University of Belgrade (RS)
- VA Connecticut Healthcare System (US)
- Valley Medical Center (US)
- Institute for Cardiovascular Diseases of Vojvodina (RS)
Publication Details
- Journal
- Journal of the Society for Cardiovascular Angiography & Interventions
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jscai.2025.103989
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00