Efficacy and Safety of a Novel Triple Single-Pill for Uncontrolled Hypertension
In patients with uncontrolled hypertension, a novel triple single-pill containing candesartan cilexetil, amlodipine, and chlorthalidone improved BP control at 12 weeks and had a reasonable safety profile. (Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT for Systemic Arterial Hypertension [OPTION TREAT]; NCT05920005).
Authors
- Marco Antônio Mota Gomes (ORCID: https://orcid.org/0000-0002-6652-1533)
- Raquel Littério de Bastos (ORCID: https://orcid.org/0000-0002-7556-7701)
- Luiz Aparecido Bortolotto (ORCID: https://orcid.org/0000-0002-4865-6442)
- Patrícia O. Guimarães (ORCID: https://orcid.org/0000-0002-0626-2250)
- Miguel Nasser Hissa
- Andréa Araújo Brandão (ORCID: https://orcid.org/0000-0002-7040-396X)
- Flávio Danni Fuchs (ORCID: https://orcid.org/0000-0002-1191-0523)
- Otávio Berwanger (ORCID: https://orcid.org/0000-0002-4972-2958)
- Vagner Madrini (ORCID: https://orcid.org/0000-0002-1116-6554)
- Fabiana G. Marcondes‐Braga (ORCID: https://orcid.org/0000-0002-2533-5638)
- Paula Bretas Ullmann Fernandes (ORCID: https://orcid.org/0000-0002-0358-7359)
- Murillo de Oliveira Antunes (ORCID: https://orcid.org/0000-0001-8071-924X)
- Vivienne Carduz Castilho (ORCID: https://orcid.org/0000-0003-0784-6642)
- Fábio Serra Silveira (ORCID: https://orcid.org/0000-0002-2924-7328)
- João Soares Felício (ORCID: https://orcid.org/0000-0003-4002-988X)
- Charlene Troiani do Nascimento (ORCID: https://orcid.org/0000-0002-9495-7094)
- Érida Magaton (ORCID: https://orcid.org/0000-0001-7256-2828)
- Mônica Camelo Pessoa de Azevedo Albuquerque (ORCID: https://orcid.org/0000-0002-2882-6563)
- Odílson Marcos Silvestre (ORCID: https://orcid.org/0000-0002-5538-7455)
- Maura G Lapa
- Maria H Vidotti
- Luiz Otávio da Silva (ORCID: https://orcid.org/0009-0004-5101-8726)
- Camila Santos N Albuquerque (ORCID: https://orcid.org/0009-0001-0320-5138)
- Caio A.M. Tavares (ORCID: https://orcid.org/0000-0002-0080-1954)
- Elizabeth Do Esp Cestario
- Carlos Antonio Rodrigues Terra Filho
Institutions
- Universidade Federal do Acre (BR)
- The George Institute for Global Health (GB)
- Diabetes Australia (AU)
- Hospital Israelita Albert Einstein (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Fundação de Apoio a Pesquisa do Estado de Goiás (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Centro Paulista de Investigação Clinica (BR)
- Department of Aerospace Science and Technology (BR)
- Hospital Regional de Presidente Prudente (BR)
- Hospital Municipal São José (BR)
- Santa Casa de Votuporanga (BR)
- Centro Universitário Cesmac (BR)
- Hospital do Coração (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Libbs (Brazil) (BR)
- Universidade Federal do Pará (BR)
- Universidade São Francisco (BR)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102175
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00