Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation
PROMIS domains were reliable and correlated with modified Rankin Scale score and symptoms in fCCM, identifying affected domains beyond physical functioning. Future studies should determine whether changes in health domains are associated with fCCM disease severity and further evaluate clinical usefulness of PROMIS.
Authors
- Cornelia Lee (ORCID: https://orcid.org/0000-0003-3769-431X)
- Charles E. McCulloch (ORCID: https://orcid.org/0000-0002-1279-6179)
- Ludmila Pawlikowska (ORCID: https://orcid.org/0000-0003-2182-9953)
- Leslie Morrison (ORCID: https://orcid.org/0000-0002-0092-193X)
- Marc C. Mabray (ORCID: https://orcid.org/0000-0001-7355-6833)
- Rachel Vassar (ORCID: https://orcid.org/0000-0001-5466-066X)
- Jeffrey Nelson (ORCID: https://orcid.org/0000-0002-0219-473X)
- Michael T. Lawton (ORCID: https://orcid.org/0000-0002-1887-3980)
- Amy Akers
- Sudhakar Vadivelu (ORCID: https://orcid.org/0000-0003-1419-5673)
- Joseph M. Zabramski (ORCID: https://orcid.org/0000-0001-7914-4071)
- Shantel Weinsheimer (ORCID: https://orcid.org/0000-0001-7486-9110)
- Edward R. Smith (ORCID: https://orcid.org/0000-0002-6317-8450)
- Blaine L. Hart (ORCID: https://orcid.org/0000-0001-5207-1087)
- Michel Torbey (ORCID: https://orcid.org/0000-0001-8187-9683)
- Nerissa Ko (ORCID: https://orcid.org/0000-0002-3439-0559)
- Helen Kim (ORCID: https://orcid.org/0000-0002-1937-354X)
- Douglas A. Marchuk (ORCID: https://orcid.org/0000-0002-3110-6671)
- Issam A. Awad (ORCID: https://orcid.org/0000-0003-1510-602X)
- Cynthia Tsang (ORCID: https://orcid.org/0000-0001-9017-6269)
- Atif Zafar (ORCID: https://orcid.org/0000-0002-2738-5225)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Barrow Neurological Institute (US)
- University of California, San Francisco (US)
- Oklahoma City University (US)
- University of Chicago (US)
- Boston Children's Museum (US)
- Children's Hospital (TN)
- Digital Research Alliance of Canada
- University of Oklahoma (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1161/jaha.124.035926
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00