DIA-based proteomics reveals anti-inflammatory role of DL-3- <i>n</i> -butylphthalide in cerebral small vessel disease-induced brain injury in hypertensive rat
Our findings demonstrated that NBP exerts neuroprotection in CSVD probably by suppressing TLR4/MyD88/NF-κB-mediated neuroinflammation. This study provides the evidence of NBP's therapeutic mechanisms in CSVD, suggesting its potential as a targeted anti-inflammatory treatment.
Authors
- Zhe Su (ORCID: https://orcid.org/0000-0003-4101-8429)
- Yingxiao Ji
- Fang‐Ming Wang (ORCID: https://orcid.org/0000-0002-9191-3248)
- Litao Li (ORCID: https://orcid.org/0000-0001-7925-764X)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7181-6021)
- Jingru Zhao (ORCID: https://orcid.org/0000-0003-1184-2775)
- Juan Sun
Institutions
- Hebei Medical University (CN)
- Hebei North University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Translational Neuroscience
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/tnsci-2025-0381
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China