Evaluating the Implementation Success of an Intensity‐Adapted Guideline for Pediatric Acute Myeloid Leukemia in Malawi: An Observational‐Implementation Study Protocol

Acute myeloid leukemia (AML) is most often incurable in low-resource settings. To address this challenge, the International Society of Paediatric Oncology (SIOP) developed an intensity-adapted AML practice guideline in 2019. Here, we present the protocol of an observational-implementation study evaluating the SIOP guideline in Malawi. The purpose of this manuscript is to present a novel application of hybrid effectiveness-implementation designs adaptable to a wide spectrum of pediatric hematology-oncology diseases and contexts. Here, we propose hybrid designs as an option for teams in low-resource settings to evaluate current practice and generate much-needed evidence to inform adoption decisions regarding adapted treatment strategies.

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Publication Details

Journal
Pediatric Blood & Cancer
Published
2025-08-29
DOI
https://doi.org/10.1002/pbc.32005
Primary Topic
Health Policy Implementation Science
Type
article
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article

Evaluating the Implementation Success of an Intensity‐Adapted Guideline for Pediatric Acute Myeloid Leukemia in Malawi: An Observational‐Implementation Study Protocol

Nmazuo Ozuah, Carl E. Allen, Mina C. Hosseinipour, Shaun Bulsara et al.
Pediatric Blood & Cancer
Health Policy Implementation Science
article

Evaluating the Implementation Success of an Intensity‐Adapted Guideline for Pediatric Acute Myeloid Leukemia in Malawi: An Observational‐Implementation Study Protocol

Nmazuo Ozuah, Carl E. Allen, Mina C. Hosseinipour, Shaun Bulsara, Rizine Mzikamanda, Noel Mwango, Rachel E. Rau, Casey L. McAtee, Gertjan J.L. Kaspers, Susan Galloway Hilsenbeck, Jane R. Montealegre, Grace Chirwa, Dennis Phalula
article en

Abstract

Acute myeloid leukemia (AML) is most often incurable in low-resource settings. To address this challenge, the International Society of Paediatric Oncology (SIOP) developed an intensity-adapted AML practice guideline in 2019. Here, we present the protocol of an observational-implementation study evaluating the SIOP guideline in Malawi. The purpose of this manuscript is to present a novel application of hybrid effectiveness-implementation designs adaptable to a wide spectrum of pediatric hematology-oncology diseases and contexts. Here, we propose hybrid designs as an option for teams in low-resource settings to evaluate current practice and generate much-needed evidence to inform adoption decisions regarding adapted treatment strategies.

Pediatric Blood & CancerVol. 72(11)
University of North Carolina at Chapel Hill (US), The University of Texas MD Anderson Cancer Center (US), University of Malawi (MW), Baylor College of Medicine (US), University of Washington (US), Kamuzu Central Hospital (MW), Emma Kinderziekenhuis (NL), Lilongwe University of Agriculture and Natural Resources (MW), Princess Máxima Center (NL), Christian Health Association of Malawi (MW), Texas Children's Hospital (US), Amsterdam University Medical Centers (NL), Vrije Universiteit Amsterdam (NL)
Openalex Percentile: Top 64%
Health Policy Implementation Science
DOIOpen Access PDFOpenAlex
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