Phenotypic Changes in a Monocyte Cluster with High Interleukin‐1 Beta Expression during Long‐Term Anti‐ <scp>CD20</scp> Therapy
Our single-cell analysis identified a unique peripheral IL1B<sup>high</sup> monocyte cluster with a suggested CNS-infiltrating cellular phenotype that may explain its lower abundance in the blood of untreated compared to anti-CD20 treated MS patients. Treatment-associated changes in this population may contribute to the non-B cell related effects of anti-CD20 therapy. ANN NEUROL 2025;98:1283-1298.
Authors
- Maria L. Elkjaer (ORCID: https://orcid.org/0000-0002-8596-142X)
- Mhaned Oubounyt (ORCID: https://orcid.org/0000-0001-5011-6683)
- Zsolt Illés (ORCID: https://orcid.org/0000-0001-9655-0450)
- Karina Damsbo
- Jesper B. Moeller (ORCID: https://orcid.org/0000-0001-8786-8037)
- Mie Waede (ORCID: https://orcid.org/0000-0002-7458-9597)
- Jan Baumbach (ORCID: https://orcid.org/0000-0002-0282-0462)
- Morten F. Gjerstorff (ORCID: https://orcid.org/0000-0002-0845-1952)
- Christina Kingo
- Mads Thomassen
- Maiken Joergensen
Institutions
- Universität Hamburg (DE)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Zero to Three (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1002/ana.78004
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Scleroseforeningen
- Jascha Fonden
- Novo Nordisk
- Syddansk Universitet
- Novo Nordisk Fonden
- Klinisk Institut, Syddansk Universitet