PFKFB3-Mediated Glycolytic Metabolic Reprogramming Regulates Inflammatory Response in Dry Eye Disease
Hyperosmotic stress activated the NF-κB pathway through PFKFB3-dependent glycolytic reprogramming, forming a vicious metabolic-inflammatory cycle. Targeting PFKFB3 may block this interaction and provide a novel therapeutic strategy for DED.
Authors
- Yu Alex Zhang (ORCID: https://orcid.org/0000-0001-7795-6252)
- Kaiye Zhang
- Xiaodan Huang (ORCID: https://orcid.org/0000-0001-8521-4718)
- Yujie Mou
- Xiaojie Wan
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1167/iovs.66.11.76
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Zhejiang University