Gout and Chronic Renal Failure in Conakry: Study of Clinical Characteristics and Associated Factors

Introduction:The Modification of Diet in Renal Disease (MDRD) equation is used to estimate glomerular filtration rate (GFR) from creatinine levels.Gout is caused by excess uric acid in the blood.If renal failure is a known factor in hyperuricemia.The objective was to describe the clinical characteristics of gout patients with chronic renal failure admitted to the Rheumatology Department of the Ignace Deen National Hospital and to identify associated factors. Material and Method:This was a 26-month case-control study of patients admitted or hospitalized for gout (cases), compared with patients managed in the department for other causes (controls) during the same period.The two groups were matched for age and gender.Results: Mean age was 55.5 11.7 years for cases and 55.4 11.6 years for controls; male gender predominated in both groups.Civil servants were the most commonly affected socio-professional category; joint pain was the main reason for consultation (100%); the character was inflammatory (62.26% for cases and 35.85% for controls); the knee was the most frequent location (49.06%).Chronic polyarticular gout was the most common clinical form, followed by gout attacks.Chronic renal failure was found in most patients:Stage I: 18.7%; Stage II: 47.17%; Stage III: 30.19%;Stage IV: 1.89%; Stage V: 1.89%.Hypertension was associated with gout. Conclusion:Calculation of renal function by MDRD revealed cases of renal failure at all stages, with no significant association between gout and renal failure.